What is Ximelagatran used for?

Ximelagatran was studied for treating atrial fibrillation, blood clots (thromboembolism), and recurrent thrombophlebitis.

Is Ximelagatran still available?

No, Ximelagatran has been withdrawn from the market.

Why was Ximelagatran withdrawn?

It was withdrawn due to reports of severe liver injury during long-term use (more than 11 days).

How does Ximelagatran work in the body?

Ximelagatran acts as a thrombin inhibitor to prevent blood clotting.

Can Ximelagatran cause liver damage?

Yes, there is a known risk of severe liver injury with Ximelagatran, especially during longer treatments.

How is Ximelagatran taken?

Ximelagatran is an oral medication taken by mouth.

ximelagatran | CAS 192939-46-1 | ZXIBCJHYVWYIKI

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Thrombin inhibitor

Ximelagatran is an oral small molecule drug that works as a thrombin inhibitor. It was studied for treating conditions like atrial fibrillation and blood clots, but it has been withdrawn from the market due to concerns regarding severe liver injury during long-term use.

How it worksXimelagatran works by inhibiting thrombin, which is an enzyme in the body that helps blood clot.

Used for

Recurrent thrombophlebitisThromboembolismAtrial fibrillation

Conditions

Recurrent thrombophlebitisThromboembolismAtrial fibrillation

Class

Thrombin inhibitorSmall moleculeCardiovascular

How to take

FormsOral

RoutesOral

This drug has been withdrawn from the market in the European Union due to risks of severe liver injury during treatments lasting longer than 11 days.

Key warnings

·Severe liver injury may occur during longer-term treatment (more than 11 days).

Side effects

Serious

·Severe liver injury

Seek help if

·Signs of liver injury

Talk to your doctor

Monitor

·Liver function

Questions to ask

·Why was this medication withdrawn?
·What are the risks of liver injury with blood thinners?
·What are the alternatives for treating atrial fibrillation?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.

How to take

Key warnings

Side effects

Talk to your doctor

Frequently asked questions (6)