What is Triheptanoin used for?

Triheptanoin is used to provide calories and fatty acids for adults and children with confirmed long-chain fatty acid oxidation disorders (LC-FAOID).

Can I take Triheptanoin if I have pancreatic issues?

No, you should avoid Triheptanoin if you have pancreatic insufficiency because your body may not be able to absorb it properly.

What are the most common side effects of Triheptanoin?

The most common side effects are stomach-related, including nausea, vomiting, diarrhea, and abdominal pain.

Is Triheptanoin safe to take while pregnant?

There is currently no data available on the risks of using Triheptanoin during pregnancy.

How should I take Triheptanoin?

It is an oral liquid that should be mixed into food or medical formula and divided into at least four doses per day.

Are there any drugs that interact with Triheptanoin?

You should avoid taking pancreatic lipase inhibitors, like Orlistat, with Triheptanoin as it may make the treatment less effective.

Can Triheptanoin be used in children?

Yes, the safety and effectiveness of Triheptanoin have been established for pediatric patients.

Can I use PVC feeding tubes with Triheptanoin?

No, you should not use polyvinyl chloride (PVC) materials to dose or store Triheptanoin.

triheptanoin | CAS 620-67-7 | PJHKBYALYHRYSK

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Medium-chain triglyceride supplement

How it worksTriheptanoin is a medium-chain triglyceride that provides calories and fatty acids. It helps the body create energy by bypassing certain enzyme deficiencies found in long-chain fatty acid oxidation disorders.

Brand names:DOJOLVI

Used for

Treatment of adult and pediatric patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOID) as a source of calories and fatty acids.

Conditions

Long-chain fatty acid oxidation disorders (LC-FAOD)

Class

Medium-chain triglycerideMedium-chain triglyceride supplementMetabolicGastrointestinal

How to take

FormsOral liquid

RoutesOral

The target daily dose is up to 35% of a patient's total daily caloric needs. This should be split into at least four doses and mixed into semi-solid food, liquid, or medical formula during meals or snacks.

Before starting Triheptanoin, stop taking any other medium-chain triglyceride (MCT) products. Patients should be under the care of a specialist who understands dietary management for their specific condition.

Key warnings

·Feeding tube issues: Regularly check feeding tubes for proper function. Do not use tubes made of polyvinyl chloride (PVC) to dose or store Triheptanoin.
·Pancreatic insufficiency: If you have low or no pancreatic enzymes, your body may not absorb Triheptanoin properly. Avoid using this drug if you have pancreatic insufficiency.

Do not use if

·None listed

Side effects

Common

Abdominal painDiarrheaVomitingNausea

Serious

·Feeding tube dysfunction
·Reduced absorption due to pancreatic insufficiency

Seek help if

·Abdominal pain
·Diarrhea
·Vomiting
·Nausea

Interactions

·Pancreatic lipase inhibitors (such as Orlistat): Avoid taking these with Triheptanoin because they may reduce the medicine's effectiveness.

FoodTriheptanoin should be mixed into semi-solid food, liquid, or medical formula at mealtimes or snacks.

Special populations

PregnancyThere is no data available regarding the risk of major birth defects or miscarriage from using Triheptanoin in pregnant women. If you become pregnant while taking this medicine, notify your healthcare provider.

PediatricTriheptanoin has been shown to be safe and effective for use in pediatric patients.

GeriatricClinical studies have not specifically tested how patients 65 years of age or older respond to Triheptanoin compared to younger adults.

Talk to your doctor

Monitor

·Feeding tube functionality and integrity
·Gastrointestinal symptoms like diarrhea or abdominal pain

Questions to ask

·How should I calculate my daily caloric intake for Triheptanoin dosing?
·Are there specific foods I should mix this liquid with?
·How will my pancreatic enzyme levels affect this medication?
·What feeding tube materials are safe to use with this drug?

Pharmacokinetics

BioavailabilityFollowing oral administration, triheptanoin is extensively hydrolyzed to heptanoate and glycerol by pancreatic lipases in the intestines. Exposure of triheptanoin in human plasma is minimal.

MetabolismTriheptanoin is extensively hydrolyzed to heptanoate and glycerol by pancreatic lipases in the intestines.

Practical

StorageStore at 20° to 25°C (68° to 77°F). Do not freeze. It can be used for up to 9 months after opening, but do not exceed the expiration date. Do not use PVC or polystyrene containers for storage or dosing.

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.