What is Nintedanib used for?

Nintedanib is used in adults to treat idiopathic pulmonary fibrosis (IPF), certain chronic progressive lung diseases, and systemic sclerosis-associated lung disease.

How should I take OFEV?

You should take 150 mg orally twice a day, roughly 12 hours apart, and always take it with food.

Can Nintedanib cause liver problems?

Yes, Nintedanib can cause elevated liver enzymes or liver injury, so you will need regular liver function tests.

What should I do if I have diarrhea while taking Nintedanib?

Diarrhea is a common side effect; your doctor may suggest staying hydrated or using medicines like loperamide to manage it.

Is Nintedanib safe to take during pregnancy?

No, Nintedanib can cause fetal harm and should not be used during pregnancy.

Can children take Nintedanib?

The safety and effectiveness of Nintedanib have not been established for use in children.

What are the signs of liver problems to watch for?

Watch for yellowing of the skin or eyes, dark urine, pain on the right side of the stomach, or easy bruising.

Does Nintedanib interact with other medications?

Yes, certain drugs that affect liver enzymes (like St. John's wort or rifampicin) can change how Nintedanib works in your body.

nintedanib | CAS 656247-17-5 | CPMDPSXJELVGJG

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Kinase inhibitor

Nintedanib (brand name OFEV) is a medicine used to treat certain lung diseases that cause scarring, such as idiopathic pulmonary fibrosis (IPF) and other progressive lung diseases. It works by blocking specific enzymes (kinases) that contribute to the scarring process.

How it worksNintedanib is a kinase inhibitor that works by blocking signals in the body that lead to lung scarring.

Brand names:Ofev

Used for

Idiopathic pulmonary fibrosis (IPF)Chronic progressive scarring lung diseases (ILDs)Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

Conditions

Idiopathic pulmonary fibrosisChronic fibrosing interstitial lung diseasesSystemic sclerosis-associated interstitial lung disease

Class

Kinase inhibitorRespiratoryGastrointestinalHepatic

How to take

FormsOral capsule

RoutesOral

The standard dose is 150 mg taken by mouth twice a day, about 12 hours apart, with food.

People with mild liver problems may need a lower dose of 100 mg twice daily. Always take this medicine with food.

Key warnings

·Liver health: Nintedanib can cause liver injury. Regular liver function tests are required.
·Pregnancy: This drug can cause harm to an unborn baby. Women of childbearing age should have a pregnancy test before starting treatment.
·Gastrointestinal issues: There is a risk of stomach or intestinal holes (perforation) and bleeding.
·Blood clots: There is a risk of serious blood vessel events.

Do not use if

·None listed

Side effects

Common

DiarrheaNauseaStomach painVomitingDecreased appetiteHeadacheWeight lossHigh blood pressureIncreased liver enzymes

Serious

·Liver injury
·Blood clots (arterial thromboembolic events)
·Bleeding risk
·Gastrointestinal perforation (holes in the stomach or intestines)
·Kidney-related protein in urine
·Fetal harm

Seek help if

·Yellowing of skin or eyes
·Dark or tea-colored urine
·Severe stomach pain
·Easy bruising or bleeding

Interactions

·Medicines that block or speed up certain liver enzymes (like P-gp or CYP3A4 inhibitors/inducers) can change how much Nintedanib is in your body.
·Examples of drugs to watch out for include ketoconazole, erythromycin, rifampicin, carbamazepine, phenytoin, and St. John's wort.

FoodNintedanib should be taken with food.

Special populations

PregnancyNintedanib can cause serious harm or death to a fetus. If you are pregnant or planning to become pregnant, you must discuss the risks with your doctor.

PediatricThe safety and effectiveness of Nintedanib have not been proven in children. Studies in young people did not show it was effective for treating scarring lung diseases.

GeriatricNintedanib has been used in many older adults in clinical trials. No major differences in safety or effectiveness were found for people 65 or older compared to younger adults.

Talk to your doctor

Monitor

·Liver enzyme levels
·Pregnancy status
·Gastrointestinal symptoms
·Blood pressure

Questions to ask

·What are the risks to my liver while taking Nintedanib?
·How often will I need liver function tests?
·How should I manage diarrhea while on this medication?
·Are my other medications safe to take with OFEV?

Pharmacokinetics

MetabolismNintedanib is a substrate of P-gp and, to a minor extent, CYP3A4.

Practical

OverdoseIf you take too much, stop the medicine and seek medical help for supportive care. Most reported cases of high doses resulted in side effects similar to normal use.

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.