Is IBUFENAC still available?

No, IBUFENAC has been withdrawn from use.

What was IBUFENAC used for?

IBUFENAC was used as an analgesic to relieve pain and an anti-inflammatory to reduce swelling.

Why was IBUFENAC taken off the market?

It was withdrawn due to reports of liver toxicity and jaundice.

Can IBUFENAC cause liver problems?

Yes, IBUFENAC is associated with hepatotoxicity, which is damage to the liver.

Jaundice is a condition where the skin or eyes turn yellow, often caused by liver issues related to drugs like IBUFENAC.

How does IBUFENAC work in the body?

It works by inhibiting cyclooxygenase, an enzyme involved in pain and inflammation.

ibufenac | CAS 1553-60-2 | CYWFCPPBTWOZSF

Loading compound...

Analgesic (pain reliever) and Anti-inflammatory

IBUFENAC was a medication used as a pain reliever and to reduce inflammation. However, it has been withdrawn from use due to concerns regarding liver toxicity and jaundice.

How it worksIBUFENAC works as a cyclooxygenase inhibitor, which helps to reduce pain and inflammation.

Used for

Pain reliefReducing inflammation

Conditions

Painful conditionsInflammatory conditions

Class

AnalgesicAnti-inflammatoryAnalgesic (pain reliever) and Anti-inflammatoryHepatic (Liver)

How to take

This drug has been withdrawn from the market and is no longer in use due to safety concerns regarding liver health (hepatotoxicity) and jaundice reported in the United Kingdom in 1968.

Key warnings

·IBUFENAC has been linked to liver toxicity and jaundice, which led to its withdrawal from use.

Side effects

Common

Liver damage (hepatotoxicity)Jaundice (yellowing of the skin or eyes)

Serious

·Liver toxicity

Seek help if

·Yellowing of skin or eyes
·Signs of liver distress

Talk to your doctor

Monitor

·Liver function
·Skin or eye color (jaundice)

Questions to ask

·Are there safer alternatives to IBUFENAC for pain relief?
·How can I monitor my liver health when taking anti-inflammatories?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.

How to take

Key warnings

Side effects

Talk to your doctor

Frequently asked questions (6)