What is Kerendiia used for?

Kerendiia is used to lower the risk of kidney disease progression, heart failure, and heart attack in adults with type 2 diabetes and chronic kidney disease.

Can Kerendiia cause high potassium?

Yes, Kerendiia can cause hyperkalemia (high potassium), so your doctor will monitor your blood levels regularly.

What should I do if I miss a dose of Kerendiia?

The provided text does not specify instructions for missed doses.

Can I take Kerendiia with grapefruit juice?

No, you should avoid eating grapefruit or drinking grapefruit juice while taking Kerendiia.

Is Kerendiia safe to take if I am pregnant?

There is currently no data on the risks of Kerendiia use during pregnancy in humans.

Can I crush Kerendiia tablets?

Yes, if you cannot swallow them whole, you can crush them and mix them with water or soft foods like applesauce just before taking them.

Does Kerendiia affect older adults differently?

No, studies show no major differences in how safe or effective Kerendiia is for older patients compared to younger ones.

What are the most common side effects of Kerendiia?

The most common side effects are high potassium, low blood pressure, and low sodium levels.

finerenone | CAS 1050477-31-0 | BTBHLEZXCOBLCY

Loading compound...

Mineralocorticoid receptor antagonist

Kerendiia (finerenone) is a prescription medicine used to lower the risk of kidney disease progression, heart failure, and heart-related death in adults with chronic kidney disease linked to type 2 diabetes. It can also be used to reduce certain heart-related risks in adults with specific types of heart failure. Because it can increase potassium levels in your blood, your doctor will need to monitor your blood work regularly.

How it worksKerendiia works by blocking a specific receptor (the mineralocorticoid receptor) that, when overactive, can cause inflammation and scarring in the heart and kidneys.

Brand names:KERENDIA

Used for

Reducing the risk of kidney disease worsening in adults with type 2 diabetes and chronic kidney diseaseReducing the risk of kidney failure and cardiovascular death in adults with type 2 diabetes and chronic kidney diseaseReducing the risk of heart attack in adults with type 2 diabetes and chronic kidney diseaseReducing the risk of hospitalization for heart failure in adults with type 2 diabetes and chronic kidney diseaseReducing the risk of heart failure hospitalization and urgent heart failure visits in adults with heart failure and a left ventricular ejection fraction (LVEF) of 40% or higher

Conditions

Chronic kidney disease (CKD)Type 2 diabetes (T2DM)Heart failure

Class

Mineralocorticoid receptor antagonistnsMRAsRenalCardiovascular

How to take

FormsTablet

RoutesOral

The starting dose is usually 10 mg or 20 mg once daily, depending on your kidney function and potassium levels. Your doctor may adjust this dose after 4 weeks.

Tablets can be taken with or without food. If you have trouble swallowing whole tablets, they can be crushed and mixed with water or soft foods like applesauce right before you take them.

Key warnings

·High potassium (Hyperkalemia): Kerendiia can increase potassium levels in your blood, which can be dangerous. This risk is higher if you have kidney problems or high potassium to begin with.
·Worsening kidney function: In patients with heart failure, Kerendiia may cause kidney function to get worse.

Do not use if

·People who are allergic to any part of Kerendiia
·People with adrenal insufficiency
·People taking strong CYP3A4 inhibitors

Side effects

Common

High potassium levels (hyperkalemia)Low blood pressure (hypotension)Low sodium levels (hyponatremia)

Serious

·High potassium levels (hyperkalemia)
·Worsening of kidney function in patients with heart failure

Seek help if

·Symptoms of high potassium
·Worsening kidney function

Interactions

·Do not use Kerendiia if you are taking strong CYP3A4 inhibitors.
·Avoid using grapefruit or grapefruit juice while taking Kerendiia.
·Avoid using strong or moderate CYP3A4 inducers.
·If you take moderate or weak CYP3A4 inhibitors, your doctor should monitor your potassium levels closely.
·Monitor potassium levels closely if taking other medications that increase potassium or affect how your kidneys work.

FoodKerendiia can be taken with or without food. High-fat or high-calorie foods do not significantly change how the medicine works.

Special populations

PregnancyThere is no data on how Kerendiia affects pregnancy in humans. Animal studies showed some risk of birth defects, but it is unclear how much this applies to people.

PediatricKerendiia has not been tested for safety or effectiveness in children under 18 years old.

GeriatricKerendiia can be used in older adults. Studies showed no major differences in safety or effectiveness for patients aged 65 or older compared to younger patients.

Talk to your doctor

Monitor

·Serum potassium levels
·eGFR (kidney function)

Questions to ask

·What are my potassium levels?
·How often do I need blood tests for my kidney function?
·Should I avoid grapefruit while on Kerendiia?
·Are my other medications safe to take with Kerendiia?

Pharmacokinetics

OnsetC max achieved between 0.5 and 1.25 hours after dosing

Bioavailability44%

Protein binding90%

MetabolismUndergoes metabolism; is a CYP3A4 substrate

Practical

OverdoseIf you think you have taken too much Kerendiia, stop taking it immediately. The main risk of an overdose is high potassium levels.

StorageStore at room temperature between 68°F and 77°F.

Ingredients

Allergens

lactose

Inactive

lactose monohydratecellulose microcrystallinecroscarmellose sodiumhypromellosemagnesium stearatesodium lauryl sulfatetitanium dioxidetalcferric oxide redferric oxide yellow

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.