What is Difluprednate used for?

Difluprednate is used to treat pain and swelling in the eye after surgery or to treat a condition called endogenous anterior uveitis.

Can Difluprednate cause eye pressure issues?

Yes, using Difluprednate for 10 days or longer may increase your eye pressure, so your doctor should monitor you for glaucoma.

Will Difluprednate cause cataracts?

Prolonged use of Difluprednate may lead to the formation of cataracts.

Can I use Difluprednate if I have a viral eye infection?

No, Difluprednate should not be used if you have active viral diseases like herpes simplex in the eye.

Is Difluprednate safe to use while pregnant?

Animal studies showed potential risks to the fetus, so you should only use Difluprednate during pregnancy if your doctor says it is necessary.

What should I do if my eye symptoms don't get better?

If your symptoms do not improve within 2 days of using Difluprednate, you should contact your doctor for a re-evaluation.

Can Difluprednate be used in children?

Yes, studies in children aged 0 to 3 years showed a safety profile similar to other common steroid eye drops.

How often do I apply Difluprednate eye drops?

Depending on your condition, you may need to use it 4 times a day, followed by a tapering period directed by your doctor.

difluprednate | CAS 23674-86-4 | WYQPLTPSGFELIB

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Corticosteroid (Anti-inflammatory)

Difluprednate is a steroid eye drop used to treat swelling and pain in the eye following surgery or for certain types of eye inflammation called uveitis. It works by reducing the body's inflammatory response, but long-term use requires monitoring because it can increase eye pressure or cause cataracts.

How it worksDifluprednate works by blocking the chemicals in your body that cause inflammation, swelling, and redness.

Brand names:TRAVASOL 3.5% SULFITE FREE W/ ELECTROLYTES IN PLASTIC CONTAINER, RENAMIN W/O ELECTROLYTES, AMINOSYN II 3.5% W/ ELECTROLYTES IN DEXTROSE 25% W/ CALCIUM IN PLASTIC CONTAINER, CLINIMIX E 2.75/10 SULFITE FREE W/ ELECT IN DEXTROSE 10% W/ CALCIUM IN PLASTIC CONTAINER, DUREZOL, AMINESS 5.2% ESSENTIAL AMINO ACIDS W/ HISTADINE, TRAVASOL 5.5% SULFITE FREE W/ ELECTROLYTES IN PLASTIC CONTAINER

Used for

Inflammation and pain after eye surgeryEndogenous anterior uveitis (eye inflammation)

Conditions

Post-ocular surgery inflammationEndogenous anterior uveitis

Class

CorticosteroidAnti-inflammatoryCorticosteroid (Anti-inflammatory)Ocular (Eyes)

How to take

FormsOphthalmic emulsion (eye drops)

RoutesTopical (applied to the eye)

For surgery recovery, use one drop 4 times daily starting 24 hours after surgery for two weeks, then reduce to 2 times daily for one week before tapering off. For uveitis, use one drop 4 times daily for 14 days, then taper as directed by a doctor.

Always follow your doctor's specific instructions for tapering your dose; do not stop using the drops suddenly without medical guidance.

Key warnings

·Using this drug for 10 days or longer requires monitoring of eye pressure to prevent glaucoma.
·Long-term use may lead to the formation of cataracts.
·Steroids can mask or worsen eye infections, especially viral or fungal infections.
·Using steroids after cataract surgery may slow down the healing process.

Do not use if

·Active viral diseases of the cornea or conjunctiva (such as herpes simplex, vaccinia, or varicella)
·Mycobacterial eye infections
·Fungal eye diseases

Side effects

Common

Blurred visionEye irritationEye painRedness of the eyeLight sensitivity

Serious

·Increased eye pressure (glaucoma)
·Cataracts
·Eye infections
·Perforation (hole) in the eye

Seek help if

·Vision changes
·Increased eye pain
·Signs of infection

Interactions

·Aristocort
·Emflaza
·Pediapred
·Solu-cortef
·Alrex
·Cortifoam
·Desowen
·Decadron-LA
·Rayos
·Meti-derm
·Kenacort
·Korlym
·Cortef

Special populations

PregnancyIn animal studies, difluprednate caused issues with fetal weight and development. It is classified as Pregnancy Category C, so use during pregnancy should only be done if the benefits outweigh the risks.

BreastfeedingIt is not certain how much of this drug reaches breast milk. Since steroids in milk can affect infant growth, use caution if breastfeeding.

PediatricDifluprednate has been studied in children aged 0 to 3 years for inflammation after cataract surgery and showed a safety profile similar to prednisolone acetate.

GeriatricNo significant differences in safety or effectiveness were found between elderly patients and younger adults.

Talk to your doctor

Monitor

·Intraocular pressure (eye pressure)
·Vision changes
·Signs of infection
·Healing progress after surgery

Questions to ask

·Should I have my eye pressure checked while using this?
·How long should I continue using these drops after my surgery?
·Is it safe to use this if I have a history of herpes in my eye?

Pharmacokinetics

BioavailabilitySystemic absorption after ocular instillation is limited; blood levels of the active metabolite DFB remained below quantification limits in studies.

MetabolismDifluprednate undergoes deacetylation in the body to form its active metabolite, 6α, 9-difluoroprednisolone 17-butyrate (DFB).

Ingredients

Inactive

boric acidcastor oilglycerinpolysorbate 80water for injectionsodium acetateedetatate disodiumsodium hydroxidesorbic acid

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.