What is Clemizole used for?

Clemizole is being researched for use in treating Dravet syndrome, Lennox-Gastaut syndrome, liver cancer, and Hepatitis C.

Is Clemizole an approved medicine?

No, Clemizole is currently in the research and testing phases and is not yet widely approved for medical use.

Are there heart risks associated with Clemizole?

Laboratory studies have shown that Clemizole may have potential effects on heart function (cardiotoxicity).

Does Clemizole interact with other medications?

Clemizole may interfere with how the body processes certain drugs through liver enzymes like CYP1A2, CYP2D6, and CYP3A4.

What are the research phases for Clemizole?

Clemizole is currently in Phase 1 or Phase 2 clinical development for various conditions.

What is the chemical name for Clemizole?

The chemical name is 1-[(4-chlorophenyl)methyl]-2-[(pyrrolidin-1-yl)methyl]-1H-1,3-benzodiazole hydrochloride.

clemizole | CAS 442-52-4 | CJXAEXPPLWQRFR

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Research compound

Clemizole is a chemical compound being studied for its potential to treat various conditions, including certain types of seizures and liver-related issues. It is currently in the research phase and is not a standard approved medication for general use.

How it worksWhile the exact way it works in the body is still being researched, Clemizole is being studied for its effects on neurological and liver conditions.

Used for

Dravet syndrome (a type of epilepsy)Lenox-Gastaut syndrome (a severe form of epilepsy)Hepatocellular carcinoma (liver cancer)Hepatitis C virus infection

Conditions

Dravet syndromeLennox-Gastaut syndromeHepatocellular carcinomaHepatitis C virus infection

Class

Small moleculeResearch compoundNervous systemHepatic (Liver)

How to take

Clemizole is currently in the research phase (Phase 1 and 2 studies) and is not yet an FDA-approved drug for these conditions.

Key warnings

·Laboratory data indicates potential risks to heart health (hERG inhibition and cardiotoxicity).

Side effects

Serious

·Potential for heart-related toxicity (cardiotoxicity) observed in laboratory studies.

Seek help if

·Seek medical help if you experience heart-related symptoms while participating in studies involving Clemizole.

Interactions

·Clemizole may interact with other drugs processed by the CYP1A2, CYP2D6, and CYP3A4 enzymes in the liver.

Talk to your doctor

Monitor

·Heart health/cardiac function
·Liver enzyme levels

Questions to ask

·What are the potential heart risks of Clemizole?
·How might Clemizole interact with my current liver medications?
·What stage of clinical testing is Clemizole currently in?

Pharmacokinetics

MetabolismClemizole is associated with the inhibition of CYP1A2, CYP2D6, and CYP3A4 enzymes.

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.