What is Bexagliflozin used for?

Bexagliflozin is used alongside diet and exercise to help adults manage blood sugar levels in type 2 diabetes.

Can I take Bexagliflozin if I have type 1 diabetes?

No, Bexagliflozin is not recommended for people with type 1 diabetes.

Should I take Bexagliflozin with food?

You can take Bexagliflozin either with or without food, but it is best taken in the morning.

What should I do if I miss a dose of Bexagliflozin?

Take the missed dose as soon as possible, but do not take two doses at once to catch up.

Can I crush my Bexagliflozin tablets?

No, you should not crush or chew the Bexagliflozin tablets.

What are the most common side effects of Bexagliflozin?

The most common side effects are yeast infections, urinary tract infections, and needing to urinate more often.

Can Bexagliflozin cause low blood sugar?

Yes, especially if you are already taking insulin or other medications that lower blood sugar.

What should I do before having surgery while taking Bexagliflozin?

You should stop taking Bexagliflozin for at least 3 days before a major surgery if possible.

What should I do if I suspect an overdose of Bexagliflozin?

Contact a Poison Help line or a medical professional for guidance.

bexagliflozin | CAS 1118567-05-7 | BTCRKOKVYTVOLU

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SGLT2 inhibitor

How it worksBexagliflozin works by blocking a protein in the kidneys called SGLT2. This prevents the kidneys from taking glucose back into the blood, which causes more sugar to be removed from the body through urine.

Brand names:BRENZAVVY

Used for

Improving blood sugar control in adults with type 2 diabetes

Conditions

Type 2 diabetes mellitus

Class

SGLT2 InhibitorSGLT2 inhibitorEndocrineRenal

How to take

FormsTablet

RoutesOral

The usual dose is 20 mg taken once a day in the morning. You can take it with or without food, but do not crush or chew the tablet.

If you miss a dose, take it as soon as you can, but do not take two doses at once to make up for a missed one. If you are having surgery or fasting for a long time, your doctor may tell you to stop taking it for at least 3 days.

Missed dose: Take the missed dose as soon as possible. Do not double the next dose.

Key warnings

·Risk of ketoacidosis, especially in people with type 1 diabetes.
·Risk of lower limb amputation; monitor for signs of infection or ulcers.
·Risk of volume depletion and kidney injury; ensure you are hydrated.
·Risk of serious genital or perineal infections.
·Risk of low blood sugar if taken with insulin or other drugs that lower blood sugar.

Do not use if

·Do not use if you have a known allergy to bexaqliflozin or any of its ingredients.

Side effects

Common

Yeast infections (female genital mycotic infections)Urinary tract infectionsIncreased urination

Serious

·Diabetic ketoacidosis (a serious condition involving high blood sugar and ketones)
·Lower limb amputation
·Severe dehydration or kidney injury
·Severe genital or perineal infections (such as Fournier’s Gangrene)
·Low blood sugar (hypoglycemia) when used with insulin

Seek help if

·Pain, swelling, or redness in the genital or perineal area
·Signs of ketoacidosis
·Signs of lower limb infection or ulcers
·Symptoms of severe dehydration

Interactions

·Drugs that increase UGT enzymes may make Bexagliflozin less effective.
·Taking Bexagliflozin with insulin or insulin secretagogues increases the risk of low blood sugar.
·Bexagliflozin may lower the amount of lithium in your blood.
·Other SGLT2 inhibitors like Jardiance, Farxiga, Invokana, or Steglatro may interact.

FoodTaking Bexagliflozin with food may delay how quickly the drug reaches its peak level in your body.

Special populations

PregnancyBexagliflozin is not recommended during the second and third trimesters of pregnancy due to potential risks to the kidneys found in animal studies.

PediatricThe safety and effectiveness of Bexagliflozin have not been tested in children.

GeriatricBexagliflozin has been studied in many patients aged 65 and older, including those with heart disease risks, with no overall differences in effectiveness found.

Talk to your doctor

Monitor

·Signs of infection in the genital or perineal area
·Signs of dehydration or kidney issues
·Signs of ketoacidosis
·Blood sugar levels
·Signs of infection or ulcers on the lower limbs

Questions to ask

·What is my current kidney function (eGFR)?
·How will Bexagliflozin affect my lithium levels?
·Should I adjust my insulin dose when starting Bexagliflozin?
·How long should I stop Bexagliflozin before my upcoming surgery?

Pharmacokinetics

OnsetPeak plasma concentrations reached between 2–4 hours after taking the dose.

MetabolismUGT enzymes may affect drug exposure.

Practical

OverdoseIf you take too much, contact a Poison Help line or a medical professional immediately. Supportive care should be provided based on symptoms.

Ingredients

Allergens

lactose

Inactive

colloidal silicon dioxideglyceryl dibehenatelactose monohydratemagnesium stearatemicrocrystalline cellulosepolyethylene oxidepoloxamer 188FD&C Blue #1/Brilliant Blue FCF Aluminum LakeFD&C Blue #2/Indigo Carmine Aluminum Lakemacrogol 3350partially hydrolyzed polyvinyl alcoholtalctitanium dioxide

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.