What is DOPTELET used for?

DOPTELET is used to treat low platelet counts in adults with chronic liver disease and in adults or children with certain immune-related platelet disorders.

Can I swallow DOPTELET SPRINKLE capsules whole?

No, you should not swallow the capsules whole. Instead, open the capsule and mix the granules with soft food or liquid, then swallow immediately.

What are the risks of blood clots with AVASTROMBOPAAG?

AVASTROMBOPAAG can be associated with blood clots (thromboembolic complications), so it is important to monitor your platelet counts and watch for symptoms.

Can I take DOPTELET on an empty stomach?

No, you should take both DOPTELET tablets and DOPTELET SPRINKLE with food.

Is DOPTELET safe to take if I am pregnant?

Animal studies show a potential for fetal harm, so you should be aware of the risks and discuss pregnancy with your doctor.

What should I do if I take too much DOPTELET?

An overdose can cause your platelet count to rise too high, potentially leading to blood clots. Contact a medical professional or the Poison Help line immediately.

Are there age limits for using DOPTELET?

DOPTELET SPRINKLE is approved for children ages 1 to 5, and DOPTELET tablets are approved for children aged 6 and older.

Can other medications affect how DOPTELET works?

Yes, certain drugs that affect the CYP2C9 and CYP3A4 enzymes can change how much DOPTELET is in your body, which might require a dose change.

avatrombopag | CAS 570406-98-3 | OFZJKCQENFPZBH

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Thrombopoietin receptor agonist

AVASTROMBOPAAG (brand names DOPTELET and DOPTELET SPRINKLE) is a medication used to treat low platelet counts (thrombocytopenia). It is specifically used for adults with chronic liver disease who are preparing for a medical procedure, as well as adults and children (ages 1 and older) with certain types of immune-related platelet disorders.

How it worksAVASTROMBOPAAG works by acting on the thrombopoietin receptor to help increase your platelet count.

Brand names:Doptelet Sprinkle, DOPTELET

Used for

Low platelet counts in adults with chronic liver disease scheduled for a procedureLow platelet counts in adults with chronic immune thrombocytopenia (ITP)Low platelet counts in children (1 year and older) with persistent or chronic immune thrombocytopenia (ITP)

Conditions

Chronic liver disease related thrombocytopeniaChronic immune thrombocytopenia (ITP)

Class

Thrombopoietin receptor agonistHematologic

How to take

FormsDOPTELET tablets, DOPTELET SPRINKLE capsules

RoutesOral

DOPTELET tablets and DOPTELET SPRINKLE are not interchangeable on a milligram-to-milligram basis. Tablets should be taken with food. For the SPRINKLE version, open the capsule and mix the granules with soft food or liquid; swallow immediately and do not swallow the capsule whole. Dosing for liver disease is typically taken for 5 days before a procedure, while ITP dosing starts at 20 mg once daily and is adjusted based on platelet counts.

Always take DOPTELET or DOPTELET SPRINKLE with food.

Key warnings

·There is a risk of blood clots (thrombotic/thromboembolic complications) when using DOPTELET, especially in patients with chronic liver disease or immune thrombocytopenia. It is important to monitor platelet counts and watch for signs of blood clots.

Do not use if

·None listed

Side effects

Common

HeadacheFatigueNauseaAbdominal painFeverCoughUpper respiratory tract infection

Serious

·Blood clots (thrombotic or thromboembolic complications)
·Portal vein thrombosis
·Excessively high platelet counts

Seek help if

·Signs of blood clots
·Excessively high platelet counts

Interactions

·Drugs that are moderate or strong dual inhibitors or inducers of the CYP2C9 and CYP3A4 enzymes may require dose adjustments of DOPTELET.

FoodDOPTELET and DOPTELET SPRINKLE should be taken with food.

Special populations

PregnancyAnimal studies suggest DOPTELET may cause harm to a fetus. While human data is limited, pregnant women should be aware of the potential risks to the baby.

PediatricDOPTELET tablets are used for children aged 6 years and older with persistent or chronic ITP. DOPTELET SPRINKLE is used for children aged 1 to 5 years with the same condition.

GeriatricThere is not enough data from clinical studies to determine if older adults (65+) respond differently than younger patients, though many older adults were included in the studies.

Talk to your doctor

Monitor

·Platelet counts
·Signs and symptoms of blood clots (thromboembolic events)

Questions to ask

·What is my risk for blood clots while taking DOPTELET?
·How often will my platelet counts be monitored?
·Are my other medications going to interact with DOPTELET?
·Should I adjust my dose if I start a new medication?

Pharmacokinetics

Protein bindingHighly bound to plasma proteins

MetabolismInvolves CYP2C9 and CYP3A4 enzymes

ExcretionApproximately 6% is excreted through the kidneys

Practical

OverdoseAn overdose of DOPTELET may cause platelet counts to rise too high, which could lead to blood clots. There is no known antidote. If an overdose is suspected, contact a medical professional or a Poison Help line.

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.