What is avanafil used for?

Avanafil is used to treat erectile dysfunction in adult men.

How long before sex should I take avanafil?

You should take avanafil approximately 15 minutes before sexual activity.

Can I take avanafil with food?

Yes, avanafil tablets may be taken with or without food.

What should I do if an erection lasts too long after taking avanafil?

If an erection lasts longer than 4 hours, you should seek emergency medical treatment.

Can I take avanafil if I take nitrate medication for chest pain?

No, you should not use avanafil if you are using any form of organic nitrate.

What are the most common side effects of avanafil?

Common side effects include headache, flushing, nasal congestion, back pain, and nasopharyngitis.

Is avanafil safe for elderly patients?

Yes, no dose adjustments are needed for age alone, though older individuals may be more sensitive to the drug.

Can avanafil cause vision or hearing problems?

Yes, you should stop taking avanafil and seek medical help immediately if you experience sudden vision loss or sudden hearing loss.

avanafil | CAS 330784-47-9 | WEAJZXNPAWBCOA

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Phosphodiesterase 5A inhibitor

Avanafil is a prescription medicine used to treat erectile dysfunction (ED) in adult men. It works by helping blood flow into the penis during sexual stimulation. It should be taken as needed, and it is important to avoid using it with certain other medications, especially nitrates used for chest pain.

How it worksAvanafil helps increase blood flow to the penis by blocking an enzyme called PDE5. This allows the natural chemicals released during sexual stimulation to work more effectively to relax smooth muscles and allow blood to enter.

Brand names:STENDRA

Used for

Erectile dysfunction in adult males

Conditions

Erectile dysfunction

Class

PDE5 inhibitorPhosphodiesterase 5A inhibitorReproductive system

How to take

FormsOral tablet

RoutesOral

The starting dose is usually 100 mg taken about 15 minutes before sexual activity. Depending on how you respond, the dose may be adjusted between 50 mg and 200 mg. Do not take more than one dose in a 24-hour period.

Avanafil can be taken with or without food. Sexual stimulation is necessary for the drug to work.

Key warnings

·Do not use if you are taking any form of organic nitrate (often used for chest pain).
·Seek emergency medical help if an erection lasts more than 4 hours.
·Stop using and call a doctor immediately if you have sudden vision loss or sudden hearing loss.
·Avoid using this drug if sexual activity is not recommended due to your heart health.
·Using this with alpha-blockers, blood pressure medications, or large amounts of alcohol may cause dangerously low blood pressure.

Do not use if

·Use of any organic nitrates
·Use of guanylate cyclase (GC) stimulants
·Known hypersensitivity to any part of the tablet

Side effects

Common

HeadacheFlushingNasal congestionNasopharyngitisBack pain

Serious

·Erection lasting longer than 4 hours
·Sudden loss of vision in one or both eyes
·Sudden decrease or loss of hearing
·Low blood pressure (hypotension)

Seek help if

·Erection lasting more than 4 hours
·Sudden loss of vision
·Sudden loss of hearing

Interactions

·Organic nitrates (such as those used for chest pain)
·Guanylate cyclase (GC) stimulants like riociguat or veri Ciguate
·Strong CYP3A4 inhibitors (like ketoconazole, ritonavir, or erythromycin)
·Moderate CYP3A4 inhibitors (dose must be limited to 50 mg)
·Alpha-blockers and other blood pressure medications
·Alcohol (especially more than 3 units)

FoodAvanafil can be taken with or without food, though a high-fat meal may slow down how quickly the drug is absorbed.

AlcoholUsing substantial amounts of alcohol (more than 3 units) with avanafil may cause low blood pressure.

Special populations

PregnancyAvanafil is not intended for use in females. There is no data regarding the risks of using this drug in pregnant women.

PediatricAvanafil is not for use in children; safety and effectiveness in people under 18 have not been established.

GeriatricNo dose changes are specifically required for older adults, but some seniors may be more sensitive to the medication.

Talk to your doctor

Monitor

·Blood pressure
·Vision changes
·Hearing changes
·Duration of erections

Questions to ask

·Is my heart healthy enough for sexual activity?
·Are any of my current blood pressure medications unsafe to take with avanafil?
·Should I avoid alcohol when taking this medication?
·What should I do if I experience sudden vision or hearing changes?

Pharmacokinetics

OnsetRapidly absorbed with a median T max of 30 to 45 minutes in the fasted state.

Protein bindingHighly bound to plasma proteins.

MetabolismInvolves CYP3A4 pathway.

ExcretionNot significantly eliminated in the urine.

Practical

OverdoseIn case of overdose, standard medical support should be used. Dialysis is not expected to help clear the drug quickly because it binds strongly to blood proteins.

Ingredients

Inactive

fumaric acidhydroxyl propyl celluloselow-substituted hydroxyl propyl cellulosemagnesium stearatemannitolsodium bicarbonate

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.