What is ERIVEDGE used for?

ERIVEDGE is used to treat adults with metastatic basal cell carcinoma or locally advanced basal cell carcinoma that cannot be treated with surgery or radiation.

Can I take ERIVEDGE with food?

Yes, you can take ERIVEDGE once daily either with or without food.

What should I do if I miss a dose of VISMODEGIB?

If you miss a dose, simply take the next dose at your regular scheduled time.

Is ERIVEDGE safe to take if I am pregnant?

No, ERIVEDGE can cause severe birth defects or fetal death and should not be used during pregnancy.

How long should I use birth control while on ERIVEDGE?

Females should use effective contraception during treatment and for 24 months after the final dose.

What are the most common side effects of ERIVEDGE?

Common side effects include muscle spasms, hair loss, changes in taste, nausea, and fatigue.

Can I crush ERIVEDGE capsules?

No, you should swallow the capsules whole and not open or crush them.

What should I do if I have a severe skin rash while taking VISMODEGIB?

Severe skin reactions like Stevens-Johnson syndrome require you to stop taking the medication permanently.

Vismodegib | CAS 879085-55-9 | BPQMGSKTAYIVFO

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Hedgehog pathway inhibitor

VISMODEGIB (brand name ERIVEDGE) is a prescription medicine used to treat adults with certain types of advanced skin cancer, specifically metastatic or locally advanced basal cell carcinoma that cannot be treated with surgery or radiation. It works by blocking a specific protein in the body's 'hedgehog' signaling pathway. This medication carries serious warnings regarding potential birth defects and severe skin or muscle reactions.

How it worksVISMODEGIB works by blocking a protein called Smoothened, which is part of the hedgehog signaling pathway that helps certain cancer cells grow.

Brand names:ERIVEDGE

Used for

Metastatic basal cell carcinoma in adultsLocally advanced basal cell carcinoma in adults that has come back after surgery and cannot be treated with surgery or radiation

Conditions

Basal Cell Carcinoma

Class

Hedgehog pathway inhibitorIntegumentary (Skin)Musculoskeletal

How to take

FormsOral capsule

RoutesOral

The standard dose is one 150 mg capsule taken by mouth once every day. You can take it with or without food. Swallow the capsules whole; do not crush or open them.

If you miss a dose, take it as soon as you remember, but do not double up. You may need to stop taking ERIVEDGE temporarily if you have bad side effects.

Missed dose: Resume dosing with the next scheduled dose. Do not double the dose.

Key warnings

ERIVEDGE can cause severe birth defects or fetal death if taken during pregnancy. Females of reproductive potential must use effective birth control during treatment and for 24 months after the last dose. Males should use condoms during treatment and for 3 months after the last dose.

·ERIVEDGE can cause severe birth defects or fetal death if taken during pregnancy. Females of reproductive potential must use effective birth control during treatment and for 24 months after the last dose. Males should use condoms during treatment and for 3 months after the last dose.
·Risk of severe skin reactions that may require stopping the drug permanently.
·Risk of serious muscle and bone-related side effects.
·Risk of premature fusion of the growth plates in bones.

Side effects

Common

Muscle spasmsHair lossTaste changesWeight lossFatigueNauseaDiarrheaDecreased appetiteConstipationJoint painVomiting

Serious

·Severe skin reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis)
·Severe muscle or bone problems
·Potential for serious birth defects

Seek help if

·Severe skin reactions like Stevens-Johnson syndrome
·Severe muscle or bone pain
·Signs of pregnancy

Interactions

·ODOMZO
·DAURISMO

FoodFood does not change how much of the medicine is absorbed in your body.

Special populations

PregnancyERIVEDGE can cause serious harm or death to an unborn baby. Women of childbearing age should verify pregnancy status before starting and use effective contraception during and for 24 months after treatment. There is a pregnancy registry to track outcomes.

PediatricThe safety and effectiveness of ERIVEDGE have not been tested in children. In pediatric patients, it has been linked to early bone growth plate fusion and early puberty.

GeriatricThere is not enough information to know if people over 65 respond differently to ERIVEDGE than younger adults.

Talk to your doctor

Monitor

·Skin reactions
·Muscle and bone pain
·Taste changes
·Pregnancy status

Questions to ask

·What are the risks of severe skin reactions with ERIVEDGE?
·How will this affect my bone health?
·What birth control methods should I use while on this medication?
·Can I donate blood or semen while taking vismodegib?

Pharmacokinetics

BioavailabilityThe single dose absolute bioavailability of vismodegib is 32%.

Practical

StorageStore at room temperature between 20°C to 25°C (68°F to 77°F). Keep the bottle tightly closed to protect from moisture.

Ingredients

Allergens

lactosesoy

Inactive

microcrystalline celluloselactose monohydratesodium lauryl sulfatepovidonesodium starch glycolatetalcmagnesium stearate (non-bovine)gelatintitanium dioxidered iron oxideblack iron oxideshellac

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.