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Endothelin receptor antagonist
Sitaxeentan sodium is a small molecule drug that was studied as an antagonist for endothelin receptors (ET-A and ET-B). While it was investigated for conditions like pulmonary hypertension and diastolic heart failure, it has been withdrawn from the market due to concerns regarding liver toxicity.
How it worksSitaxeentan sodium works by blocking endothelin receptors (ET-A and ET-B) in the body.
Used for
pulmonary hypertensiondiastolic heart failure
Conditions
pulmonary hypertensiondiastolic heart failure
Class
Endothelin receptor antagonistcardiovascular
How to take
RoutesNot specified
This drug has been withdrawn from the market due to reports of liver toxicity/damage in the European Union and Canada around 2010.
Key warnings
- ·Sitaxeentan sodium has been withdrawn due to risks of liver toxicity and liver damage.
Side effects
Common
liver toxicity
Serious
- ·liver damage
Seek help if
- ·Signs of liver damage
Talk to your doctor
Monitor
- ·Liver function
Questions to ask
- ·Is there an alternative to Sitaxeentan sodium for pulmonary hypertension?
- ·What are the risks of liver toxicity with my current medications?
Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.