What is APHEXDA used for?

APHEXDA is used with filgrastim to move stem cells into the blood so they can be collected for transplants in patients with multiple myeloma.

Can APHEXDA cause an allergic reaction?

Yes, APHEXDA can cause severe allergic reactions or anaphylactic shock, which is why doctors provide premedication before the injection.

Is APHEXDA safe to use if I am pregnant?

No, APHEXDA can cause fetal harm and should not be used during pregnancy.

What are the most common side effects of APHEXDA?

Common side effects include pain, redness, or itching where the shot was given, as well as flushing and back pain.

Can people with leukemia take APHEXDA?

No, APHEXDA should not be used in patients with leukemia because it may mobilize leukemia cells.

How is APHEXDA administered?

It is given as a slow injection under the skin, usually 10 to 14 hours before the stem cell collection starts.

Does APHEXDA affect white blood cell counts?

Yes, APHEXDA can cause an increase in the number of white blood cells in your blood.

How should I store APHEXDA?

Store it in the original carton in a refrigerator between 2°C and 8°C (36°F to 46°F) to protect it from light.

Motixafortide | CAS 664334-36-5 | JJVZSYKFCOBILL

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Hematopoietic stem cell mobilizer

APHEXDA (motixafortide) is a medicine used to help move stem cells from the bone marrow into the bloodstream. This process makes it easier to collect these cells for a transplant in people with multiple myeloma. It is used alongside another medicine called filgrastim.

How it worksMotixafortide works by blocking a specific receptor (CXCR4) that helps keep stem cells anchored in the bone marrow. By blocking this connection, the stem cells are released into the blood so they can be collected.

Brand names:APHEXDA

Used for

Collecting stem cells for transplant in patients with multiple myeloma

Conditions

Multiple myeloma

Class

CXCR4 antagonisthematopoietic stem cell mobilizerHematopoietic stem cell mobilizerHematologic

How to take

FormsPowder for injection

RoutesSubcutaneous injection (under the skin)

The dose is based on your actual body weight. It is usually given as a slow injection about 10 to 14 hours before the cell collection process begins.

This medicine must be used with filgrastim. Patients are usually given other medications (premedication) before the injection to prevent allergic reactions.

Key warnings

·Severe allergic reactions can occur, so medical staff must be ready to treat them immediately.
·This drug should not be used in patients with leukemia because it might move leukemia cells into the blood.
·It may cause harm to an unborn baby; effective birth control should be used by women of childbearing age.
·It can cause an increase in white blood cells, which requires monitoring.

Do not use if

·People with a history of serious allergic reactions to motixafortide

Side effects

Common

Pain, redness, or itching at the injection siteItchingFlushingBack pain

Serious

·Severe allergic reactions (anaphylaxis)
·Increased white blood cell counts
·Potential release of tumor cells from the bone marrow

Seek help if

·Signs of a severe allergic reaction (anaphylaxis)
·Severe injection site reactions

Interactions

·Mozobil
·Xolremdi

Special populations

PregnancyAPHEXDA can cause harm to a fetus. Because of how it works, there is a risk to the developing baby and the placenta. Women of reproductive potential should use effective contraception.

PediatricThe safety and effectiveness of APHEXDA have not been tested in children.

GeriatricNo major differences in safety or effectiveness were found in patients aged 65 or older.

Talk to your doctor

Monitor

·Signs of anaphylaxis or hypersensitivity
·Injection site redness, itching, or pain
·White blood cell counts

Questions to ask

·What are the risks of an allergic reaction to APHEXDA?
·How will my white blood cell counts be monitored?
·What premedication will I need before my injection?
·How should I manage injection site pain?

Practical

StorageKeep in the refrigerator (36°F to 46°F) in the original box to protect it from light.

Ingredients

Inactive

mannitolhydrochloric acid

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.