Can I take Ojjaarara with food?

Yes, you can take Ojjaarara either with or without food.

What should I do if I miss a dose of Ojjaarara?

If you miss a dose, simply take your next scheduled dose the following day.

Does Ojjaarara increase the risk of infection?

Yes, Ojjaarara can increase the risk of serious infections, including bacterial, viral, and COVID-19.

What kind of blood tests will I need while on Ojjaarara?

You will need regular complete blood counts (CBC) and liver function tests (hepatic panel).

Is Ojjaarara safe to take if I am pregnant?

It should only be used during pregnancy if the benefits to the mother outweigh the potential risks to the fetus, as it may cause harm to the developing baby.

What are the most common side effects of Ojjaarara?

The most common side effects are low platelets, bleeding, bacterial infections, tiredness, dizziness, diarrhea, and nausea.

Can I crush or chew Ojjaarara tablets?

No, you should swallow the tablets whole and do not cut, crush, or chew them.

Momelotinib | CAS 1056634-68-4 | ZVHNDZWQTBEVRY

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Kinase inhibitor

Ojjaara (momeloitinib) is a medicine used to treat adults with intermediate or high-risk myelofibrosis (MF) who also have anemia. It belongs to a class of drugs called kinase inhibitors.

How it worksOjjaara works by inhibiting specific proteins in the body called JAK1 and JAK2, which are involved in certain disease processes.

Brand names:Ojjaara

Used for

Intermediate or high-risk myelofibrosis (MF) in adults with anemiaPrimary myelofibrosisSecondary myelofibrosis (occurring after polycythemia vera or essential thrombocytemia)

Conditions

Intermediate or high-risk myelofibrosis (MF)Primary myelofibrosisSecondary myelofibrosis

Class

JAK1 inhibitorJAK2 inhibitorKinase inhibitorHematologicHepaticIntegumentaryCardiovascular

How to take

FormsOral tablet

RoutesOral

The standard dose is 200 mg taken by mouth once every day.

You can take Ojjaara with or without food. Swallow the tablets whole; do not crush, chew, or cut them. If you miss a dose, take it the next day.

Missed dose: If a dose is missed, take the next scheduled dose the following day. Do not double up.

Key warnings

·Do not start Ojjaarara if you have an active infection.
·You will need regular blood tests to monitor your liver and blood cell counts.
·Watch for signs of infection, heart issues, or blood clots.
·Monitor for any severe skin rashes or signs of new cancers.

Do not use if

·None listed

Side effects

Common

Low blood platelet levels (thrombocytopenia)BleedingBacterial infectionsFatigueDizzinessDiarrheaNausea

Serious

·Increased risk of infections (including COVID-19) and hepatitis B reactivation
·Low white blood cell counts (neutropenia)
·Liver problems (hepatotoxicity)
·Severe skin reactions
·Heart-related issues (major adverse cardiovascular events)
·Blood clots (thrombosis)
·Development of new cancers

Seek help if

·Signs of infection
·Severe skin reactions
·Signs of blood clots
·Signs of heart problems
·Unexpected bleeding

Interactions

·Drugs that inhibit OAATP1B1/B3 may increase Ojjaarara levels in your body, increasing the risk of side effects.
·Ojjaarara may increase the effects of certain drugs like rosuvastatin (a cholesterol medicine). If taking rosuvastatin, start at a low dose of 5 mg and do not exceed 10 mg daily.

FoodOjjaarara can be taken with or without food.

Special populations

PregnancyAvailable data is not enough to know the exact risk to a fetus, but animal studies suggest Ojjaarara may cause harm to an embryo or fetus. Use only if the benefits to the mother outweigh the risks to the baby.

PediatricThe safety and effectiveness of Ojjaarara in children have not been established.

GeriatricNo major differences in safety or effectiveness were seen in patients aged 65 and older compared to younger adults.

Talk to your doctor

Monitor

·Signs of infection
·Hepatitis B reactivation symptoms
·Bleeding or bruising
·Skin rashes
·Heart symptoms
·Blood clot symptoms

Questions to ask

·Should I stop taking Ojjaarara if I feel an infection coming on?
·How often will I need blood tests to check my liver and blood counts?
·Are there specific medicines I should avoid while taking Ojjaarara?
·How will Ojjaarara affect my current anemia?

Pharmacokinetics

MetabolismMomeloitinib is an OAATP1B1/B3 substrate.

Practical

OverdoseThere is no specific antidote for an overdose. If an overdose is suspected, seek medical help immediately for monitoring and supportive care.

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.