What is Hydrocortisone Butyrate used for?

Hydrocortisone Butyrate is used to help soothe skin inflammation and itching from certain skin conditions.

How often should I apply Hydrocortisone Butyrate?

You should apply a thin layer to the affected skin 2 or 3 times every day, depending on the severity of your skin issue.

Can I use a bandage over Hydrocortisone Butyrate?

Yes, bandages can be used for conditions like psoriasis, but if you notice an infection, stop using the bandage immediately.

Is Hydrocortisone Butyrate safe to use while pregnant?

It should only be used during pregnancy if the benefit to you is greater than the potential risk to your baby.

Are there side effects for children using Hydrocortisone Butyrate?

Yes, children may be more sensitive and could experience growth delays or hormone changes.

What are the common skin reactions to Hydrocortisone Butyrate?

Common reactions include burning, itching, irritation, and dryness at the application site.

Can Hydrocortisone Butyrate cause skin thinning?

Yes, skin atrophy (thinning of the skin) is a possible side effect of using this medication.

Can I use Hydrocortisone Butyrate if I am breastfeeding?

You should use caution when applying this medication while nursing.

Hydrocortisone Butyrate | CAS 13609-67-1 | BMCQMVFGOVHVNG

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Glucocorticoid

Hydrocortisone Butyrate is a topical corticosteroid cream used to relieve skin inflammation and itching caused by certain skin conditions. It works by acting on glucocorticoid receptors to reduce swelling and irritation.

How it worksIt works by acting on glucocorticoid receptors to reduce inflammation, itching, and blood vessel constriction in the skin.

Brand names:LOCOID LIPOCREAM, LOCOID

Used for

Relief of skin inflammationRelief of skin itchingManagement of corticosteroid-responsive skin diseases

Conditions

Corticosteroid-responsive dermatosesPsoriasis

Class

CorticosteroidGlucocorticoidIntegumentary (Skin)

How to take

FormsCream, Ointment

RoutesTopical

Apply a thin layer to the affected area 2 or 3 times a day, depending on how severe the condition is.

Occlusive dressings (like bandages) may be used for psoriasis or stubborn conditions, but if an infection starts, stop using the dressings and seek medical care.

Key warnings

·Children may be more sensitive to this medication, which can lead to growth delays or hormone issues.
·Using occlusive dressings can increase how much of the drug is absorbed into your body.

Side effects

Common

BurningItchingIrritationDrynessSkin thinningAcne-like bumpsChanges in skin color

Serious

·Skin infection
·Skin atrophy (thinning)
·HPA-axis suppression (in children)
·Cushing's syndrome (in children)

Seek help if

·If an infection develops while using occlusive dressings, stop using them and seek medical care.

Special populations

PregnancyUse during pregnancy only if the potential benefit outweighs the risk to the baby. Large amounts or long-term use should be avoided.

BreastfeedingIt is not known if enough of the drug passes into breast milk, so use caution when applying to the skin while nursing.

PediatricChildren may be more sensitive to this drug, which can lead to hormone suppression, growth retardation, or weight gain issues.

Talk to your doctor

Monitor

·Signs of skin infection
·Skin thinning or changes in color
·Signs of hormone changes in children

Questions to ask

·Is this safe for my child's skin?
·Can I use bandages over the cream?
·How will this affect my skin thickness?

Pharmacokinetics

Protein bindingCorticosteroids are bound to plasma proteins in varying degrees.

MetabolismMetabolized primarily in the liver.

ExcretionExcreted by the kidneys.

Practical

StorageStore between 36° to 86°F.

Ingredients

Inactive

Mineral oilPolyethylene glycol

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.