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Cyclooxygenase inhibitor
Glafenine is a small molecule that works as a cyclooxygenase inhibitor. It was used to treat fever and pain, but it has been withdrawn from use due to safety concerns regarding severe allergic reactions.
How it worksGlafenine works by inhibiting the cyclooxygenase enzyme.
Used for
FeverPain
Conditions
FeverPain
Class
Cyclooxygenase inhibitorImmune system
How to take
Glafenine has been withdrawn from the market worldwide. This is due to reports of severe allergic responses and anaphylactic shock associated with its use in 1984.
Key warnings
- ·Associated with severe allergic responses, including anaphylactoid reactions and reports of anaphylactic shock.
Do not use if
- ·Glafenine is withdrawn and should not be used due to risks of severe allergic reactions.
Side effects
Common
Severe allergic responsesAnaphylactic shock
Serious
- ·Anaphylactoid reactions
- ·Severe immune system toxicity
Seek help if
- ·Severe allergic reactions
- ·Anaphylactic shock
Interactions
- ·Glafenine may inhibit CYP3A4.
Talk to your doctor
Monitor
- ·Signs of severe allergic reaction
- ·Anaphylactic shock symptoms
Questions to ask
- ·What are the risks of allergic reactions with this type of medication?
- ·Are there safer alternatives for fever and pain?
Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.