What is Estriol used for?

Estriol is used to improve skin texture, firmness, and hydration that changes due to lower estrogen, and to help with menopause discomfort.

How should I apply Estriol cream?

Clean and dry the skin first, then gently massage a pea-sized amount into the area twice daily.

Can I swallow Estriol?

No, Estriol is for topical use only and should not be swallowed.

Will Estriol help with my aging skin?

Yes, Estriol is designed to support skin elasticity and firmness in aging skin.

How much Estriol cream should I use?

You should use a small, pea-sized amount.

Is Estriol a hormone?

Yes, it is classified as an estrogen.

Estriol | CAS 50-27-1 | PROQIPRRNZUXQM

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Estrogen

Estriol is an estrogen receptor modulator used topically. It is primarily used to help improve skin firmness, hydration, and texture caused by declining estrogen levels, and to help relieve discomforts related to menopause.

How it worksEstriol works as an estrogen receptor modulator, meaning it interacts with estrogen receptors in the body.

Brand names:JARDIENT Estriol Cream

Used for

Improving skin tone and texture related to declining estrogenSupporting skin hydration, firmness, and elasticity in aging skinRelieving discomforts associated with menopause

Conditions

MenopauseAtrophic Vaginitis

Class

EstrogenHormoneIntegumentary systemReproductive system

How to take

FormsTopical cream

RoutesTopical application

Apply a pea-sized amount to a clean, dry area twice a day or as directed by a healthcare professional.

For topical use only. Massage gently into the skin until it is fully absorbed.

Special populations

PregnancyInformation regarding use during pregnancy is not provided in the source material.

GeriatricThe product is used to support aging skin and menopause symptoms.

Talk to your doctor

Questions to ask

·Is Estriol appropriate for my menopause symptoms?
·How long until I see skin improvements with Estriol?
·Are there side effects to using Estriol topically?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.

How to take

Special populations

Talk to your doctor

Frequently asked questions (6)