What is Entospletinib used for?

Entospletinib is being studied to treat several types of blood cancer, such as acute myeloid leukemia and various forms of lymphoma.

How does Entospletinib work?

Entospletinib works by inhibiting a specific protein in the body called tyrosine-protein kinase SYK.

Is Entospletinib approved for use?

Entospletinib is currently in clinical trial phases (up to Phase 3) and is not listed as a standard approved medication in this data.

What types of lymphoma can Entospletinib treat?

It is being researched for follicular lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma.

What is the chemical structure of Entospletinib?

Entospletinib is a small molecule with the chemical formula C23H21N7O.

Is Entospletinib a natural product?

Yes, according to the available data, Entospletinib is classified as a natural product.

Entospletinib | CAS 1229208-44-9 | XSMSNFMDVXXHGJ

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Tyrosine-protein kinase SYK inhibitor

Entospletinib (also known as Entospleti) is a small molecule drug currently being studied in clinical trials. It works by inhibiting a protein called tyrosine-protein kinase SYK. It is being investigated for various types of blood cancers, including certain leukemias and lymphomas.

How it worksEntospletinib works by blocking an enzyme called tyrosine-protein kinase SYK, which may help stop the growth of certain cancer cells.

Used for

Acute myeloid leukemiaFollicular lymphomaChronic lymphocytic leukemiaDiffuse large B-cell lymphomaMantle cell lymphoma

Conditions

acute myeloid leukemiafollicular lymphomachronic lymphocytic leukemiadiffuse large B-cell lymphomaMantle cell lymphoma

Class

SYK inhibitorSmall moleculeTyrosine-protein kinase SYK inhibitorHematologic

How to take

This drug is currently in the research and clinical trial phases (up to Phase 3) and is not yet widely available for general use.

Talk to your doctor

Questions to ask

·Is Entospletinib appropriate for my specific type of lymphoma?
·What phase of clinical trials is Entospletinib currently in?
·Are there known side effects for Entospletinib?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.

How to take

Talk to your doctor

Frequently asked questions (6)