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Topical anesthetic

Dyclonine Hydrochloride (brand name DycloPro) is a topical anesthetic used to numb mucous membranes. It can be used for procedures involving the mouth, throat, esophagus, or urethra, and can also help relieve pain from oral ulcers or gag reflexes.

How it worksIt works by blocking sodium channels in your cells, which stops pain signals from being sent.

Brand names:DYCLONE

Used for
Numbing mucous membranes (like the mouth, throat, esophagus, or urethra) before endoscopic proceduresBlocking the gag reflexRelieving pain from oral ulcers or stomatitisRelieving pain from ano-genital lesions
Conditions
Mucous membrane anesthesiaGag reflexOral ulcersStomatitisAno-genital lesions
Class
Local AnestheticTopical AnestheticTopical anestheticCentral nervous systemCardiovascular systemIntegumentary system

How to take

FormsTopical solution (0.5% and 1%)
RoutesTopical

The amount needed depends on the area being numbed and how much blood flow is in that tissue. For the 1% solution, a typical dose is between 4 mL and 20 mL, though up to 30 mL (300 mg) may be used.

The lowest amount needed to achieve numbing should be used. Once opened, the solution can be used for up to 7 days. Do not inject this into tissue or use it in the eyes as it can cause irritation. Use with extreme caution if there is an infection or severe injury in the area, as the drug may be absorbed into the bloodstream too quickly. Resuscitative equipment and oxygen should be available during use to manage possible reactions.

Key warnings

  • ·Do not inject into tissue or use in the eyes.
  • ·Use with caution if the area has an infection (sepsis) or severe injury, as it may be absorbed too fast.
  • ·Medical staff should have oxygen and resuscitation tools ready when using this drug.

Do not use if

  • ·Do not use if you are allergic to Dyclonine Hydrochloride or any of its ingredients.

Side effects

Common

LightheadednessNervousnessDizzinessDrowsinessConfusionBlurred or double visionNausea or vomitingTremors or twitchingSkin lesions or allergic reactions

Serious

  • ·Convulsions or seizures
  • ·Unconsciousness
  • ·Difficulty breathing or respiratory arrest
  • ·Slow heart rate (bradycardia)
  • ·Low blood pressure (hypotension)
  • ·Heart failure or cardiac arrest

Seek help if

  • ·Difficulty breathing
  • ·Seizures
  • ·Unconsciousness
  • ·Slow heart rate
  • ·Severe skin reaction

Interactions

  • ·CYKLX
  • ·XCOPRI
  • ·MULTAQ
  • ·ZONEGRAN
  • ·ALTAFLUOR BENOX
  • ·QUINIDEX
  • ·MYSOLINE
  • ·TOPAMAX
  • ·ZTLIDO
  • ·GEREF

Special populations

PregnancyAnimal studies have not been done. It is unknown if Dyclonine Hydrochloride harms a fetus, so it should only be used during pregnancy if clearly necessary.

BreastfeedingIt is not known if this drug passes into breast milk. Use caution if you are nursing.

PediatricThe safety and effectiveness of Dyclonine Hydrochloride in children under 12 years old have not been established.

Talk to your doctor

Monitor

  • ·Heart rate
  • ·Blood pressure
  • ·Breathing
  • ·Level of consciousness

Questions to ask

  • ·Is it safe to use this if I have an infection in my mouth?
  • ·How much of the 1% solution should I use for my procedure?
  • ·Are there interactions with my current medications like MULTAQ?

Pharmacokinetics

Onset2 to 10 minutes
DurationApproximately 30 minutes

Practical

OverdoseOverdose can cause serious issues like seizures or heart problems. Prevention is best achieved by constantly monitoring heart rate, breathing, and consciousness during use.

Ingredients

Inactive

ChlorobutanolSodium chlorideHydrochloric acidWater

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.