What is Xcopri used for?

Xcopri is used to treat partial-onset seizures in adult patients.

Can I stop taking CenobaMate suddenly?

No, you should not stop taking CenobaMate abruptly because it could cause your seizures to increase in frequency.

Will Xcopri make me feel sleepy?

Yes, sleepiness, dizziness, and fatigue are among the most common side effects of Xcopri.

Does Xcopri affect birth control?

Yes, Xcopri may make hormonal oral contraceptives less effective, so it is recommended to use a non-hormonal backup method.

What should I do if I am pregnant and taking Xcopri?

You should consider enrolling in the North American Antiepileptic Drug (NAAED) Pregnancy Registry to monitor outcomes.

Can I crush Xcopri tablets?

Yes, Xcopri tablets can be crushed and mixed with water to be taken by mouth or through a feeding tube.

What are the risks to my liver while taking CenobaMate?

Clinically significant liver injury has occurred, so your doctor will likely check your liver function before you start and during treatment.

Can I drive while taking Xcopri?

You should not drive or operate machinery until you know how Xcopri affects you, as it can cause drowsiness.

Cenobamate | CAS 913088-80-9 | GFHAXPJGXSQLPT

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Anti-epileptic (seizure medication)

CenobaMate (brand name Xcopri) is a prescription medication used to treat partial-onset seizures in adults. It works by affecting specific channels in the brain to reduce repetitive nerve firing. It is a Schedule V controlled substance and must be used as directed by a healthcare provider.

How it worksCenobaMate works by slowing down repetitive electrical signals in the brain. It does this by acting on GABA-A receptors and inhibiting certain sodium channels.

Brand names:XCOPRI

Used for

Partial-onset seizures in adults

Conditions

Partial-onset seizures

Class

Anti-epilepticAnticonvulsantAnti-epileptic (seizure medication)Nervous system

How to take

FormsOral tablet

RoutesOral

The starting dose is usually 12.5 mg once daily, which is gradually increased to a maintenance dose of 200 mg once daily. The maximum dose is 400 mg once daily.

Tablets can be taken whole or crushed and mixed with water. It can be taken with or without food.

Key warnings

·Monitor for suicidal thoughts or behaviors.
·Watch for signs of liver injury; doctors may need to test your liver function.
·Be careful with drugs that affect heart rhythm.
·Do not stop taking this medication suddenly without talking to a doctor, as it may increase seizures.
·Avoid driving or operating machinery until you know how this medicine affects you, as it can cause sleepiness or fatigue.

Do not use if

·Known allergy to cenobaMate or any of its ingredients
·Family history of Short QT syndrome

Side effects

Common

SleepinessDizzinessFatigueDouble visionHeadache

Serious

·Severe allergic reactions (DRESS/multi-organ hypersensitivity)
·Changes in heart rhythm (QT shortening)
·Suicidal thoughts or behaviors
·Liver injury
·Neurological issues like extreme tiredness
·Increased seizure frequency if stopped suddenly

Seek help if

·Signs of a severe allergic reaction
·Suicidal thoughts
·New or worsening liver issues
·Changes in heart rhythm

Interactions

·Phenytoin (may require dose reduction)
·Phenobarbital and Clobazam (may require dose reduction)
·Lamotrigine and Carbamazepine (may require dose increase)
·Oral contraceptives (Xcopri may make birth control less effective; use a non-hormonal backup method)
·Other CNS depressants or alcohol (may increase sleepiness/drowsiness)

FoodXcopri can be taken with or without food.

AlcoholWhile studies in healthy subjects showed no major differences in attention or memory when combined with alcohol, caution is advised due to the risk of increased sedation.

Special populations

PregnancyThere is a pregnancy registry for women taking anti-epileptic drugs like Xcopri. Animal studies showed risks to developing fetuses, such as increased mortality and lower birth weights. There is not enough data to know the exact risk to humans.

PediatricThe safety and effectiveness of Xcopri in children have not been established.

GeriatricThere isn't enough research on people aged 65 and older. Doctors may start older patients on a lower dose due to changes in liver, kidney, or heart function.

Talk to your doctor

Monitor

·Liver function (ALT, AST, bilirubin)
·Suicidal thoughts or behaviors
·Heart rhythm (QT interval)
·Signs of multi-organ hypersensitivity (DRESS)

Questions to ask

·How will Xcopri affect my liver function?
·Should I change my birth control while taking Xcopri?
·What should I do if I feel suicidal while on this medication?
·How should I adjust my other seizure medications when starting Xcopri?

Pharmacokinetics

OnsetSteady-state plasma concentrations are reached after about two weeks of daily dosing.

BioavailabilityAt least 88% is absorbed after oral administration.

MetabolismInformation on specific metabolic pathways is not provided, though it interacts with CYP enzymes.

Practical

OverdoseThere is no specific antidote for an overdose. If an overdose is suspected, seek emergency medical help immediately. Standard medical care will focus on maintaining breathing and monitoring heart rate.

StorageInformation on specific storage temperature is not provided in the text.

Ingredients

Allergens

lactose

Inactive

colloidal silicon dioxidelactose monohydratemagnesium stearatemicrocrystalline cellulosesodium starch glycolateFD&C Blue# 2/indigo carmine aluminum lakeiron oxide rediron oxide yellowpolyethylene glycol 3350polyvinyl alcohol-part hydrolyzedtalctitanium dioxide

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.