What is GW-406381 used for?

GW-406381 is being investigated to treat pain, rheumatoid arthritis, toothaches, and osteoarthritis of the knee.

How does GW-406381 work in the body?

This drug works as a cyclooxygenase-2 inhibitor, which targets enzymes involved in inflammation.

Is GW-406381 an approved medicine?

No, GW-406381 is currently in Phase 3 clinical trials and has not yet received first approval.

What type of drug is GW-406381?

It is classified as a small molecule drug.

Is GW-406381 a natural product?

Yes, the data identifies GW-406381 as a natural product.

What should I know about the research stage of GW-406381?

It is currently in Phase 3 testing, which is a late stage of clinical research.

CHEMBL364804 | CAS 221148-46-5 | NXMZBNYLCVTRGB

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COX-2 inhibitor

GW-406381 is a small molecule being studied as a cyclooxygenase-2 (COX-2) inhibitor. It is currently in late-stage clinical research (Phase 3) for conditions such as rheumatoid arthritis and knee osteoarthritis.

How it worksGW-406381 works by inhibiting the COX-2 enzyme, which helps reduce inflammation and pain.

Used for

Rheumatoid arthritisKnee osteoarthritisToothacheGeneral pain

Conditions

Rheumatoid arthritisOsteoarthritis of the kneeToothachePain

Class

COX-2 inhibitorSmall moleculeMusculoskeletal system

How to take

Information on specific dosing and administration is not available in the provided data as this drug is still in the research phase (Phase 3).

Talk to your doctor

Questions to ask

·Is GW-406381 a suitable option for my rheumatoid arthritis?
·What are the potential risks of COX-2 inhibitors like GW-406381?
·When will GW-406381 be available for general use?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.

How to take

Talk to your doctor

Frequently asked questions (6)