What is Butoconazole Nitrate used for?

Butoconazole Nitrate is used to treat local vaginal yeast infections caused by Candida.

Can I use condoms while using Butoconazole Nitrate cream?

No, the mineral oil in this cream can weaken latex condoms or diaphragms; avoid using them for 72 hours after treatment.

Can I use Butoconazole Nitrate if I am breastfeeding?

It is unknown if this drug passes into human milk, so caution should be used when nursing.

What are the common side effects of Butoconazole Nitrate?

Common side effects include vaginal itching, burning, soreness, swelling, or pelvic pain.

How much Butoconazole Nitrate cream should I use?

The recommended dose is one applicatorful, which is approximately 5 grams of cream.

Is Butoconazole Nitrate safe for children?

No, the safety and effectiveness of this cream in children have not been established.

Why do I need a doctor to confirm my yeast infection first?

A doctor should confirm the diagnosis with tests like cultures to ensure Butoconazole Nitrate is the right treatment.

Butoconazole Nitrate | CAS 64872-77-1 | ZHPWRQIPPNZNML

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Antifungal

Butoconazole nitrate is an antifungal cream used to treat vaginal yeast infections caused by Candida. It works by stopping the growth of the fungus, but it can weaken latex products like condoms, so they should not be used for 72 hours after treatment.

How it worksIt is an imidazole derivative that likely works by blocking the production of ergosterol, which changes the fungal cell membrane and stops the fungus from growing.

Brand names:FEMSTAT, FEMSTAT 3, BUTOCONAZOLE NITRATE

Used for

Local treatment of vulvovaginal candidiasis (yeast infections caused by Candida)

Conditions

Vulvovaginal candidiasis

Class

AntifungalImidazoleVaginal/Reproductive

How to take

FormsVaginal cream

RoutesVaginal

The standard dose is one applicatorful of cream (about 5 grams) inserted into the vagina.

A diagnosis of the infection should be confirmed by a doctor using medical tests like KOH smears or cultures before starting treatment.

Key warnings

·Mineral oil in this cream can weaken latex or rubber products, such as condoms or vaginal diaphragms. Do not use these products within 72 hours after using the cream.
·Repeated or hard-to-treat yeast infections can be an early sign of HIV in women who are at risk.

Do not use if

·Do not use if you have a known allergy or hypersensitivity to any of the ingredients in this product.

Side effects

Common

Vaginal or vulvar burningItchingSorenessSwellingPelvic or abdominal painAbdominal cramping

Serious

·Signs of HIV infection (recurrent yeast infections that are hard to treat can sometimes be an early sign in women at risk)

Seek help if

·Severe burning, itching, or swelling
·Severe pelvic or abdominal pain

Interactions

·Diflucan
·Oravig
·Noxafil
·Ecoza
·Luzu
·TZ-3
·VFEND
·Nizoral
·Monistat 3
·Ganite

Special populations

PregnancyThe safety and effectiveness of butoconazole nitrate in pregnant women have not been established.

BreastfeedingIt is not known if this drug passes into breast milk. Use caution if you are nursing.

PediatricThe safety and effectiveness of this medication in children have not been studied.

Talk to your doctor

Monitor

·Vaginal/vulvar burning
·Itching or soreness
·Pelvic or abdominal pain

Questions to ask

·Is my yeast infection confirmed by a culture?
·Is it safe for me to use this while pregnant or nursing?
·Could my frequent infections be a sign of something else, like HIV?

Pharmacokinetics

BioavailabilityAfter vaginal administration, 1.7% (range 1.3-2.2%) of the dose is absorbed on average.

MetabolismPeak plasma levels of the drug and its metabolites are reached between 12 and 24 hours.

Ingredients

Inactive

edetatate disodiumglyceryl monoisostearatemethylparabenmineral oilpolyglyceryl-3 oleatepropylene glycolpropylparabencolloidal silicon dioxidesorbitol solutionpurified watermicrocrystalline wax

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-25.