What is Benzbromarone used for?

Benzbromarone was used to treat gout, high uric acid levels (hyperuricemia), and certain types of pulmonary hypertension.

Is Benzbromarone still available?

Benzbromarone has been withdrawn from the market due to concerns that its risks outweigh its benefits.

Why was Benzbromarone withdrawn?

It was withdrawn because of an unfavorable benefit-risk evaluation, notably in Portugal.

Can Benzbromarone affect my liver?

Research indicates that Benzbromarone is associated with various types of liver toxicity, including cholestasis and cirrhosis.

How is Benzbromarone taken?

Benzbromarone is an oral medication.

Benzbromarone | CAS 3562-84-3 | WHQCHUCQKNIQEC

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Uricosuric agent

Benzbromarone is a small molecule drug that was used as a uricosuric agent, meaning it helps the body get rid of uric acid. It has been studied for treating conditions like gout and hyperuricemia. However, this drug has been withdrawn from the market due to an unfavorable benefit-risk evaluation.

How it worksBenzbromarone works by inhibiting the Solute carrier family 22 member 12, which helps manage uric acid levels.

Used for

GoutHyperuricemiaIdiopathic pulmonary arterial hypertension

Conditions

GoutHyperuricemiaIdiopathic pulmonary arterial hypertension

Class

UricosuricUricosuric agentUrinary systemCardiovascular systemHepatic

How to take

FormsOral

RoutesOral

Benzbromarone has been withdrawn from the market in some regions, such as Portugal, because the risks were found to outweigh the benefits (as of 2003).

Key warnings

·The drug has been withdrawn in Portugal due to an unfavorable benefit-risk evaluation.

Side effects

Serious

·Hepatotoxicity (liver-related toxicity including cholestasis and cirrhosis)

Seek help if

·Signs of liver issues

Talk to your doctor

Monitor

·Liver function

Questions to ask

·Is there a safer alternative to Benzbromarone for my gout?
·How does this medication affect my liver function?
·Why was this medication withdrawn from the market?

Educational summary derived from FDA labeling, AI-assisted. Not medical advice — consult a healthcare professional. Updated 2026-04-26.

How to take

Key warnings

Side effects

Talk to your doctor

Frequently asked questions (6)